Rheumatologists talking about S.L.E.

Author: Sandy

Posted On: April 10, 2014

Q. Is Systemic Lupus Erythematosus hereditary?

A: S.L.E. or Systemic Lupus Erythematosus is not a hereditary disease, but there is genetic susceptibility e.g. Gene variants promoting innate immune activation, Gene variants increasing self-antigen, Gene variants promoting adaptive immune response. The environmental factors contribute to initiation of lupus and lupus flares in genetically susceptible individual.

Q. How deadly is SLE nephropathy?

A: Systemic Lupus Erythematosus is non curable and controllable. One can live for a long time with a controlled life with Lupus. The survival rate is 95% for 5 years after diagnosis. It means the 95 patients would survive for 5 years after diagnosis of SLE without Nephritis and 92% for 10 years. The remaining 5 patients may die because of the multiple organ related complications of SLE like Kidney, i.e. SLE flare and treatment related side effects.

But when a patient is correctly diagnosed as SLE Nephretis, then out of 100, 88 patients would survive for 10 years and more in comparison to the previously stated 95 patients without lupus nephretis.

However if regular medical follow-up is not been practiced then the survival rate may fluctuate.


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